In NanoBreaker, players assume the role of Jake Warren, a military cyborg torn between his human emotions and his deadly machine instinct. When the nanomachines go awry, they begin to harvest the blood of humans and the iron of buildings in an effort to construct an army of monster machines. Entire populations and whole colonies are assimilated. Only Jake can stop the onslaught.
 
The fast-paced gameplay of NanoBreaker keeps players moving through numerous futuristic stages. Featuring intuitive controls for beginners and advanced combos for expert gamers, the game's unique, transformable Plasma Blade weapon allows for a myriad of gameplay options, including slicing, grabbing, and smashing enemies. Maintaining the intense level of gameplay throughout the adventure, gamers will also experience extreme over-the-top visual CG cinematic scenes that add more depth and story to the game.